55 km to the northwest of Hama, Syria, overlooking the Ghab valley. It was fortified and enlarged by Seleucus I Nicator in 300 BC, who so named it after his Bactrian wife, Apame.
The acropolis hill is now occupied by the ruins called Kalat el-Mudik (Kŭlat el-Mudîk). The ruins of a highly ornamental character, and of an enormous extent, are still standing, the remains, probably, of the temples of which Sozomen speaks (vii. 15); part of the town is enclosed in an ancient castle situated on a hill; the remainder is to be found in the plain.
from wikipedia http://en.wikipedia.org/wiki/Apamea_%28Syria%29